纪晓昀：博士，资格副教授，主要从事心血管疾病相关研究
邮箱：412049382@qq.com
教育经历
江苏大学，医学院，医学检验专业，学士学位；
加拿大西安大略大学, 舒立克医学和牙科学院, 病理学专业，硕士学位；
江苏大学，医学院，临床检验诊断学专业，博士学位。
留学与学术工作经历
加拿大西安大略大学, 舒立克医学和牙科学院，病理学专业，硕士研究生；
加拿大西安大略大学, 舒立克医学和牙科学院，病理学与实验医学系, 研究助理；
加拿大西安大略大学, 舒立克医学和牙科学院，病理学与实验医学系, 博士后。
主要科研项目
1. 国家自然科学基金，B10细胞在自身免疫性心肌炎小鼠模型中通过调节成纤维细胞透明质酸合成缓解心肌纤维化，主要参与者，结题。
2. Canadian Institute of Health Research, Molecular basis of junctophilin-2 regulation of ryanodine receptor-2 in cardiomyocytes, 主要参与者，结题。
3. 江苏省研究生科研创新计划，B10调控成纤维细胞HA合成延缓EAM小鼠心肌纤维化进程的机制研究，主持，结题。
部分发表论文
1.Ji Xiaoyun, Zheng D, Ni R, Wang J, Shao J, Vue Z, Jr A, Song L, Fan G, Chakrabarti S, Su Z*, Peng T*. Sustained over-expression of calpain-2 induces age-dependent dilated cardiomyopathy in mice through aberrant autophagy. Acta Pharmacology Sinica. 2022; 0:1-12. (一区)
2.Ji Xiaoyun, Wan J, Chen R, Wang H, Huang L, Wang S, Su Z, Xu H*. Low frequency of IL-10-producing B cells and high density of ILC2s contribute to the pathological process in Graves' disease, which may be related to elevated-TRAb levels. Autoimmunity. 2020;53(2):78-85.
3. Abdelaziz MH, Ji Xiaoyun, Wan J, Abouelnazar FA, Abdelwahab SF, Xu H*. Mycobacterium-Induced Th1, Helminths-Induced Th2 Cells and the Potential Vaccine Candidates for Allergic Asthma: Imitation of Natural Infection. Front Immunol. 2021;12:696734. (一区)
4. Cao T, Ni R, Ding W, Ji Xiaoyun, Li L, Liao G, Lu Y, Fan GC, Zhang Z, Peng T*. MLKL-mediated necroptosis is a target for cardiac protection in mouse models of type-1 diabetes. Cardiovasc Diabetol. 2022;21(1):165. (一区)
5. Zhang M, Zhong H, Cao T, Huang Y, Ji Xiaoyun, Fan GC, Peng T*. Gamma-Aminobutyrate transminase protects against lipid overload-triggered cardiac injury in mice. Int J Mol Sci. 2022;23(4):2182.
6. Wan J, Wu Y, Huang L, Tian Y, Ji Xiaoyun, Abdelaziz MH, Cai W, Dineshkumar K, Lei Y, Yao S, Sun C, Su Z, Wang S, Xu H*. ILC2-derived IL-9 inhibits colorectal cancer progression by activating CD8+ T cells. Cancer Lett. 2021;502:34-43. (一区)
7. Huang L, Wan J, Wu Y, Tian Y, Yao Y, Yao S, Ji Xiaoyun, Wang S, Su Z, Xu H*. Challenges in adeno-associated virus-based treatment of central nervous system diseases through systemic injection. Life Sci. 2021;270:119142.
8. Wan J, Wu Y, Ji Xiaoyun, Huang L, Cai W, Su Z, Wang S, Xu H*. IL-9 and IL-9-producing cells in tumor immunity. Cell Commun Signal. 2020;18(1):50.
9. Wan J, Huang L, Ji Xiaoyun, Yao S, Hamed Abdelaziz M, Cai W, Wang H, Cheng J, Dineshkumar K, Aparna V, Su Z, Wang S, Xu H*. HMGB1-induced ILC2s activate dendritic cells by producing IL-9 in asthmatic mouse model. Cell Immunol. 2020;352:104085.
10. Jiang Y, Chen R, Shao X, Ji Xiaoyun, Lu H, Zhou S, Zong G, Xu H, Su Z*. HMGB1 silencing in macrophages prevented their functional skewing and ameliorated EAM development: Nuclear HMGB1 may be a checkpoint molecule of macrophage reprogramming. Int Immunopharmacol. 2018;56:277-84.
