Xiaoyun Ji
　　Ph.D
　　Email: 412049382@qq.com
　　Research field: cardiovascular disease

　　Education Background
　　Bachelor’s degree, Jiangsu University, Medical School.
　　Master’s degree, Western University, Schulich School of Medicine and Dentistry.
　　Ph.D degree, Jiangsu University, Medical School.

　　Academic Work Experience
　　Research Assistant, Schulich School of Medicine and Dentistry, Western University , Canada.
　　Postdoctoral Associate, Schulich School of Medicine and Dentistry, Western University, Canada.

　　Research Projects
　　National Natural Science Foundation of China, B10 cell-mediated regulation of hyaluronic acid synthesis alleviates myocardial fibrosis in a mouse model of autoimmune myocarditis, principal participant, completed.
　　Canadian Institute of Health Research, Molecular basis of junctophilin-2 regulation of ryanodine receptor-2 in cardiomyocytes, principal participant, completed.
　　Graduate Research Innovation Plan of Jiangsu Province, Mechanism study of B10 regulation of hyaluronic acid synthesis to delay the progression of myocardial fibrosis in EAM mouse model, principal investigator, completed.

　　Representative Publications
　　1.Ji Xiaoyun, Huang Y, Li H, Cao T, Zheng D, Ni R, Fan G, Douglas L, Song L, Chakrabarti S, Su Z*, Peng T*. Junctophilin-2 prevents cardiomyocyte death by blocking MURF1-mediated Junctin ubiquitination and proteasome-dependent degradation. (Under review，Cell Death and Differentiation, IF=12.4, Q1)
　　2.Ji Xiaoyun, Zheng D, Ni R, Wang J, Shao J, Vue Z, Jr A, Song L, Fan G, Chakrabarti S, Su Z*, Peng T*. Sustained over-expression of calpain-2 induces age-dependent dilated cardiomyopathy in mice through aberrant autophagy. Acta Pharmacology Sinica. 2022; 0:1-12. (IF=8.2, Q1)
　　3.Ji Xiaoyun, Wan J, Chen R, Wang H, Huang L, Wang S, Su Z, Xu H*. Low frequency of IL-10-producing B cells and high density of ILC2s contribute to the pathological process in Graves' disease, which may be related to elevated-TRAb levels. Autoimmunity. 2020;53(2):78-85.
　　4.Abdelaziz MH, Ji Xiaoyun, Wan J, Abouelnazar FA, Abdelwahab SF, Xu H*. Mycobacterium-Induced Th1, Helminths-Induced Th2 Cells and the Potential Vaccine Candidates for Allergic Asthma: Imitation of Natural Infection. Front Immunol. 2021;12:696734. (Q1)
　　5.Cao T, Ni R, Ding W, Ji Xiaoyun, Li L, Liao G, Lu Y, Fan GC, Zhang Z, Peng T*. MLKL-mediated necroptosis is a target for cardiac protection in mouse models of type-1 diabetes. Cardiovasc Diabetol. 2022;21(1):165. (Q1)
　　6.Zhang M, Zhong H, Cao T, Huang Y, Ji Xiaoyun, Fan GC, Peng T*. Gamma-Aminobutyrate transminase protects against lipid overload-triggered cardiac injury in mice. Int J Mol Sci. 2022;23(4):2182.
　　7.Wan J, Wu Y, Huang L, Tian Y, Ji Xiaoyun, Abdelaziz MH, Cai W, Dineshkumar K, Lei Y, Yao S, Sun C, Su Z, Wang S, Xu H*. ILC2-derived IL-9 inhibits colorectal cancer progression by activating CD8+ T cells. Cancer Lett. 2021;502:34-43. (Q1)
　　8.Huang L, Wan J, Wu Y, Tian Y, Yao Y, Yao S, Ji Xiaoyun, Wang S, Su Z, Xu H*. Challenges in adeno-associated virus-based treatment of central nervous system diseases through systemic injection. Life Sci. 2021;270:119142.
　　9.Wan J, Wu Y, Ji Xiaoyun, Huang L, Cai W, Su Z, Wang S, Xu H*. IL-9 and IL-9-producing cells in tumor immunity. Cell Commun Signal. 2020;18(1):50.
　　10.Wan J, Huang L, Ji Xiaoyun, Yao S, Hamed Abdelaziz M, Cai W, Wang H, Cheng J, Dineshkumar K, Aparna V, Su Z, Wang S, Xu H*. HMGB1-induced ILC2s activate dendritic cells by producing IL-9 in asthmatic mouse model. Cell Immunol. 2020;352:104085.
　　11.Jiang Y, Chen R, Shao X, Ji Xiaoyun, Lu H, Zhou S, Zong G, Xu H, Su Z*. HMGB1 silencing in macrophages prevented their functional skewing and ameliorated EAM development: Nuclear HMGB1 may be a checkpoint molecule of macrophage reprogramming. Int Immunopharmacol. 2018;56:277-84.