姓 名：田雨 性别：男
出生年月：1993年10月 籍贯：江苏 南京
一、教育经历:
1. 2016-09 至 2022-09, 江苏大学, 临床检验诊断学, 博士
2. 2011-09 至 2016-06, 青海大学, 医学检验(五年制), 学士
3. 2008-09 至 2011-06，江苏省溧水高级中学
4. 2005-06 至 2008-06，南京市溧水区洪蓝初级中学
二、科研与学术工作经历:
1. 2023-11 至 今，江苏省免疫学会青年工作委员会，委员
2. 2023-09 至 今, 江苏大学, 生命科学学院, 讲师
3. 2023-05 至 今，江苏大学，医学院，博士后
4. 2022-12 至 今, 江苏大学, 国际基因组学研究中心, 讲师
三、主持/参与的项目和课题:
1. 国家自然科学基金委员会青年基金项目，心脏驻留TLF+巨噬细胞产生的IGF-1促进心包脂肪组织累积加重心梗心脏损伤的机制研究，2025/1/1-2027/12/31，30万元，在研，主持
2. 江苏省教育厅高校基础科学（自然科学）研究面上项目，心脏驻留TLF+巨噬细胞来源的IGF-1介导PAT累积加重心梗的机制研究，2024/7-2026/7，3万元，在研，主持
3. 江苏大学——上海儒百生物科技有限公司-横向项目，HMGB1 A Box对几种人免疫细胞的影响评测，2023/4/30-2023/12/31，50万元，结题，主持
4. 江苏省社会发展重点项目，BE2019700，基于CRM基础上的促心肌细胞再生靶点的筛选及在心脏疾病综合防治中的策略研究，2019-2022，200万元，结题，参与
5. 国家自然科学基金委员会, 面上项目, 81871244, reHMGB1诱导NKp46(+) ILC3扩增分泌IL-22调控EAM小 鼠心肌纤维化的研究, 2019/1/1-2022/12/31, 56万元, 结题, 参与
四、发表SCI论文（#共同一作，*通讯作者）
1. Yin Peng, Jiang Haiqiang, Ji Xiaoyun, Xia Lin, Su Zhaoliang, Tian Yu*. Soluble TREM2 Drives Triple-Negative Breast Cancer Progression via Activation of the AKT Pathway. Int Immunopharmacol. 2024. DOI: 10.1016/j.intimp.2024.113750.
2. Yin Peng, Su Zhaoliang, Shu Xiaozheng, Dong Zhifeng, Tian Yu*. Role of TREM2 in immune and neurological diseases: Structure, function, and implications. Int Immunopharmacol. 2024. DOI: 10.1016/j.intimp.2024.113286.
3. Tian Yu, Cao Yuwen, Liu Fang, Xia Lin, Wang Chao, Su Zhaoliang. Role of Histiocyte-Derived frHMGB1 as a Facilitator in Noncanonical Pyroptosis of Monocytes/Macrophages in Lethal Sepsis. J Infect Dis. 2024. DOI: 10.1093/infdis/jiae020.
4. Tian Yu, Gong Xiangmei,Qin Demeng et al. S1PR1-dependent migration of ILC3s from intestinal tissue to the heart in a mouse model of viral myocarditis. J Leukoc Biol, 2023. DOI: 10.1093/jleuko/qiad048.
5. Tian Yu, Chen Rong,Su Zhaoliang,HMGB1 is a Potential and Challenging Therapeutic Target for Parkinson's Disease.[J] .Cell Mol Neurobiol, 2021. DOI: 10.1007/s10571-021-01170-8.
6. Tian Yu, Cao Yuwen,Chen Rong et al. HMGB1 A box protects neurons by potently inhibiting both microglia and T cell-mediated inflammation in a mouse Parkinson's disease model.[J] .Clin Sci (Lond), 2020. DOI: 10.1042/CS20200553.
7. Cao Yuwen, Tian Yu#, Liu Yueqin et al. Reg3β: A Potential Therapeutic Target for Tissue Injury and Inflammation-Associated Disorders. [J]. Int Rev Immunol, 2021. DOI: 10.1080/08830185.2020.1869731.
8. Che Yang, Tian Yu#, Chen Rong et al. IL-22 ameliorated cardiomyocyte apoptosis in cardiac ischemia/reperfusion injury by blocking mitochondrial membrane potential decrease, inhibiting ROS and cytochrome C.[J]. Biochim Biophys Acta Mol Basis Dis, 2021. DOI: 10.1016/j.bbadis.2021.166171.
9. Zhou Lining, Tian Yu#, Guo Fang et al. LincRNA-p21 knockdown reversed tumor-associated macrophages function by promoting MDM2 to antagonize* p53 activation and alleviate breast cancer development. [J]. Cancer Immunol Immunother, 2020. DOI: 10.1007/s00262-020-02511-0.
其他论文：
1. Huang Lan., Wan Jie., Wu Yinqiu., Tian Yu., Yao Yizheng., Yao Shun., Ji Xiaoyun., Wang Shengjun., Su Zhaoliang., Xu Huaxi. Challenges in adeno-associated virus-based treatment of central nervous system diseases through systemic injection. Life Sci, 2021.
2. Wan Jie., Wu Yinqiu., Huang Lan., Tian Yu., Ji Xiaoyun., Abdelaziz Mohamed Hamed., Cai Wei., Dineshkumar Kesavan., Lei Yuqing., Yao Shun., Sun Caixia., Su Zhaoliang., Wang Shengjun., Xu Huaxi ILC2-derived IL-9 inhibits colorectal cancer progression by activating CD8 T cells. Cancer Lett, 2021
3. Li Jiali., Xia Lin., Liu Fang., Tian Yu., Chen Rong., Su Zhaoliang. lncRNA187415.1 silence in BCAMs ameliorated breast cancer progression by blocking C/EBPβ-lncRNA187415.1-CISH axis and reversing pro-tumor characteristic of BCAMs. Clin Transl Med, 2021
4. Chen Wenli., Yao Shun., Wan Jie., Tian Yu., Huang Lan., Wang Shanshan., Akter Farhana., Wu Yinqiu., Yao Yizheng., Zhang Xiaochun. BBB-crossing adeno-associated virus vector: An excellent gene delivery tool for CNS disease treatment. J Control Release, 2021
5. Chen Rong., Liu Fang., Xia Lin., Che Nan., Tian Yu., Cao Yuwen., Zhang Shiqing., Xu Huaxi., Su Zhaoliang. B10 cells decrease fibrosis progression following cardiac injury partially by IL-10 production and regulating hyaluronan secretion. J Leukoc Biol, 2021
6. Chen Rong., Cao Yuwen., Tian Yu., Gu Yufeng., Lu Hongxiang., Zhang Shiqing., Xu Huaxi., Su Zhaoliang. PGE2 ameliorated viral myocarditis development and promoted IL-10-producing regulatory B cell expansion via MAPKs/AKT-AP1 axis or AhR signaling. Cell Immunol, 2020
7. Lu Hongxiang., Chen Rong., Barnie Prince Amoah., Tian Yu., Zhang Shiqing., Xu Huaxi., Chakrabarti Subrata., Su Zhaoliang. Fibroblast transdifferentiation promotes conversion of M1 macrophages and replenishment of cardiac resident macrophages following cardiac injury in mice. Eur J Immunol, 2020
