Sir Richard J. Roberts-国际基因组学研究中心

Sir Richard J. Roberts

EDUCATION
1962-1965	University of Sheffield, Sheffield, England
	B.Sc. in Chemistry
1966-1968	University of Sheffield, Sheffield, England
	Ph.D. in Organic Chemistry
POSITIONS
2005-to date	Chief Scientific Officer, New England Biolabs
1992-2005	Research Director, New England Biolabs
1986-1992	Assistant Director for Research, Cold Spring Harbor Laboratory
1972-1986	Senior Staff Investigator, Cold Spring Harbor Laboratory
1971-1972	Research Associate in Biochemistry, Harvard University
1969-1970	Research Fellow, Harvard University

AWARDS

1. Nobel Prize in Physiology or Medicine (1993)

2. Golden Plate Award, American Academy of Achievement (1994)

3. Convocation Award, Sheffield University (1994)

4. Faye Robiner Award, Ross University (1994)

5. Fellow of the Royal Society (1995)

6. Foreign Fellow, Nat’l Academy of Medical Sciences, Pakistan (1996)

7. Fellow of the American Society of Arts and Sciences (1997)

8. Fellow of the American Academy of Microbiology (1997)

9. Medicus Magnus of the Polish Academy of Medicine (1998)

10. The Gabor Medal of the Royal Society (2007)

11. Knight Bachelor (UK) (2008)

12. TiE Boston Legends and Leaders Award (2011)

13. Fellow of the American Association for Cancer Research (AACR) Academy (2013)

14. The Hans Krebs Medal of Federation of European Biochemical Societies (FEBS) (2013)

15. Dhirubhai Ambani Lifetime Achievement Award, India (2019)

PUBLICATIONS

Sir Richard J. Roberts has published a total of 261 articles in journals and 40 book chapters

Journal Articles (this decade)

Zheng, Y., Posfai, J., Morgan, R.D., Vincze, T. and Roberts, R.J. (2009) Using Shotgun Sequence Data to find Active Restriction Enzyme Genes. Nucleic Acids Research 37: e1.

Roberts, R.J., Vincze, T., Posfai, J., Macelis, D. (2010) REBASE – a database for DNA restriction and modification: enzymes, genes and genomes. Nucleic Acids Research D234-D236.

Zheng, Y., Cohen-Karni, D., Xu, D., Chin, H.G., Wilson, G. Pradhan, S., Roberts, R.J. (2010) A unique family of Mrr-like modification-dependent restriction endonucleases. Nucleic Acids Research 38: 5527-5534.

Anton, B.P., Russell, S., Vertrees, J., Kasif, S., Raleigh, E.A., Limbach, P.A., Roberts, R.J. (2010) Functional characterization of the YmcB and YqeV tRNA methylthiotransferases of Bacillus subtilis. Nucl. Acids Res. 38: 6195-6205.

Murray, I.A, Stickel, S.K. and Roberts, R.J. (2010) Sequence-specific cleavage of RNA by Type II restriction enzymes, Nucl. Acids Res. 38: 8257-8268.

Roberts, R.J. (2011) COMBREX – COMputational BRidges to EXperiments. Biochem. Soc. Trans. 39: 581-582.

Murray, I.A., Clark, T.A., Morgan, R.D., Boitano, M., Anton, B.P., Luong, K., Fomenkov, A., Turner, S.W., Korlach, J. Roberts, R.J. (2012) The methylomes of six bacteria. Nucleic Acids Research, 40: 11450-11462.

Roberts, R.J., Carneiro, M.O. and Schatz, M. (2013) The advantages of SMRT™ sequencing. Genome Biology 14: 405.

Krebes, J., Morgan, R. D., Bunk, B., Spröer, C., Luong, K., Parusel, R., ... & Roberts, R. J. (2013). The complex methylome of the human gastric pathogen Helicobacter pylori. Nucleic acids research, 42(4), 2415-2432.

Krebes, J., Morgan, R. D., Bunk, B., Spröer, C., Luong, K., Parusel, R., ... & Roberts, R. J. (2013). The complex methylome of the human gastric pathogen Helicobacter pylori. Nucleic acids research, 42(4), 2415-2432.

Roberts, R. J., Vincze, T., Posfai, J., & Macelis, D. (2014). REBASE—a database for DNA restriction and modification: enzymes, genes and genomes. Nucleic acids research, 43(D1), D298-D299.

Fomenkov, A., Lunnen, K. D., Zhu, Z., Anton, B. P., Wilson, G. G., Vincze, T., & Roberts, R. (2015). Complete genome sequence and methylome analysis of Bacillus strain x1. Genome Announc, 3(1), e01593-14.

Roberts, R. J. (2015). Ten simple rules to win a Nobel Prize. e1004084.

Xu, S. Y., Boitano, M., Clark, T. A., Vincze, T., Fomenkov, A., Kumar, S., ... & Roberts, R. J. (2015). Complete genome sequence analysis of Bacillus subtilis T30. Genome Announc., 3(3), e00395-15.

Lee, W.C., Anton, B.P., Wang, S., Baybayan, P., Singh, S., Ashby, M., Chua, E.G., Tay, C.Y., Thirriot, F., Loke, M.F., Goh, K.L., Marshall, B.J., Roberts, R.J., Vadivelu, J. (2015). The complete methylome of Helicobacter pylori UM032. BMC genomics, 16(1), 424. Wagner, M. (2015). Do it for love. Science, 348(6241), 1394-1394.

Fomenkov, A., Vincze, T., Grabovich, M. Y., Dubinina, G., Orlova, M., Belousova, E., & Roberts, R. J. (2015). Complete genome sequence of the freshwater colorless sulfur bacterium Beggiatoa leptomitiformis neotype strain D-402T. Genome announcements, 3(6).

Fomenkov, A., Vincze, T., Grabovich, M., Anton, B. P., Dubinina, G., Orlova, M., ... & Roberts, R. J. (2016). Complete genome sequence of a strain of Azospirillum thiophilum isolated from a sulfide spring. Genome announcements, 4(1).

Blaxter, M., Danchin, A., Savakis, B., Fukami-Kobayashi, K., Kurokawa, K., Sugano, S., Roberts, R.J., Salzberg, S.L., & Wu, C. I. (2016). Reminder to deposit DNA sequences. Science, aaf7672

Xu, S. Y., Klein, P., Degtyarev, S. K., & Roberts, R. J. (2016). Expression and purification of the modification-dependent restriction enzyme BisI and its homologous enzymes. Scientific reports, 6, 28579.

Anton, B. P., Harhay, G. P., Smith, T. P., Blom, J., & Roberts, R. J. (2016). Comparative methylome analysis of the occasional ruminant respiratory pathogen Bibersteinia trehalosi. PloS one, 11(8), e0161499.

Morgan, R. D., Luyten, Y. A., Johnson, S. A., Clough, E. M., Clark, T. A., & Roberts, R. J. (2016). Novel m4C modification in type I restriction-modification systems. Nucleic acids research, 44(19), 9413-9425.

Fomenkov, A., Akimov, V.N., Vasilyeva, L.V., Andersen, D.T., Vincze, T., Roberts, R.J. (2017). Complete genome and methylome analysis of psychrotrophic bacterial isolates from Lake Untersee in Antarctica. Genome announcements, 5(11).

Fomenkov, A., Vincze, T., Degtyarev, S. K., & Roberts, R. J. (2017). Complete genome sequence and methylome analysis of Acinetobacter calcoaceticus 65. Genome announcements, 5(12).

Roberts, R. J. (2017). Bibliometrics: An obituary for the impact factor. Nature, 546(7660), 600.

Roberts, R. J., Carneiro, M. O., & Schatz, M. C. (2017). Erratum to: The advantages of SMRT sequencing. Genome biology, 18(1), 156.

Fomenkov, A., Vincze, T., Grabovich, M. Y., Dubinina, G., Orlova, M., Belousova, E., & Roberts, R. J. (2017). Whole-genome sequence and methylome analysis of the freshwater colorless sulfur bacterium Thioflexothrix psekupsii D3. Genome announcements, 5(35).

Murray, I. A., Morgan, R. D., Luyten, Y., Fomenkov, A., Corrêa Jr, I. R., Dai, N., Allaw, M.B., Zhang, X., Cheng, X., & Roberts, R. J. (2017). The non-specific adenine DNA methyltransferase M. EcoGII. Nucleic acids research, 46(2), 840-848.

Alexey, F., Tamas, V., Fana, M., & Roberts, R. J. (2018). Complete Genome Sequence and Methylome Analysis of Bacillus caldolyticus NEB414. Genome announcements, 6(6).

Fomenkov, A., Vincze, T., Grabovich, M. Y., Dubinina, G., Orlova, M., Belousova, E., & Roberts, R. J. (2018). Correction for Fomenkov et al., "Complete Genome Sequence of the Freshwater Colorless Sulfur Bacterium Beggiatoa leptomitoformis Neotype Strain D-402T". Genome announcements, 6(16), e00312-18.

Fomenkov, A., Sun, Z., Vincze, T., Dubinina, G., Orlova, M., Tarlachkov, S. V., Anton, B.P., Grabovich, M.Y. & Roberts, R. J. (2018). Complete Genome Sequence of the Freshwater Bacterium Beggiatoa leptomitoformis Strain D-401. Genome Announc., 6(17), e00311-18.

Amann, R. I., Baichoo, S., Blencowe, B. J., Bork, P., Borodovsky, M., Brooksbank, C, Chain, P.S.G., Colwell, R.R., Daffonchio, D.G., Danchin, A., de Lorenzo, V., Dorrestein, P.C., Finn, R.D., Fraser, C.M., Gilbert, J.A., Hallam, S.J., Hugenholtz, P., Ioannidis, J.P.A., Jansson, J.K., Kim, J.F., Klenk, H.P., Klotz, M.G., Knight, R., Konstantinidis, K.T., Kyrpides, N.C., Mason, C.E., McHardy, A.C., Meyer, F., Ouzounis, C.A., Patrinos, A.A.N., Podar, M., Pollard, K.S., Ravel, J., Muñoz, A.R., Roberts, R.J., Rosselló-Móra, R., Sansone, S.A., Schloss, P.D., Schriml, L.M., Setubal, J.C., Sorek, R., Stevens, R.L., Tiedje, J.M., Turjanski, A., Tyson, G.W., Ussery, D.W., Weinstock, G.M., White, O., Whitman, W.B., & Xenarios, I. (2019). Consent insufficient for data release—Response. Science, 364(6439), 446-446.

PATENTS.

1. Wong-Madden, S., Roberts, R.J. (1998) Cloning and overexpression of MAP kinase. US 5,763,244.

2. Roberts, R.J., Byrd, D.R., Morgan, R.D., Patti, J., Noren, C.J. (2002) Method for screening restriction endonucleases. US 6,383,770 B1.

3. Roberts, R.J., Byrd, D.R., Morgan, R.D., Patti, J., Noren, C.J. (2004) Method for screening restriction endonucleases. US 6,689,573 B1

4. Roberts, R.J., Stickel, S. (2005) Cleavage of RNA by restriction endonucleases. US 2005/0053990A1

5. Roberts, R.J., Byrd, D.R. Morgan, R.D., Patti, J., Noren, C.J. (2005) Method for screening restriction endonucleases. US 6,905,837 B2

6. Roberts, R.J. (2005) Inferring function from shotgun sequencing data. WO2005/121946A2

7. Roberts, R.J. (2006) Inferring function from shotgun sequencing data. US2006/0014179A1

8. Roberts, R.J. (2007) Novel restriction endonucleases, DNA encoding these endonucleases and methods for identifying new endonucleases with the same or varied specificity.

9. Bitinaite, J., Vaisvila, R., Pradhan, S., Zheng, Y., Roberts, R.J., Chin, H-G, Cohen-Karni, D., Noren, C., Raleigh, E.A., & Geoffrey G. Wilson, G.G. (2010) Detection and quantification of hydroxymethylated nucleotides in a polynucleotide preparation. EP2470675B1

10. Roberts, R.J., Zheng, Y. (2008) Selection and enrichment of proteins using in vitro compartmentalization. Pub# WO2008/103900 Filed 8/28/2008.

11. Zheng, Y., Richard J. Roberts, R.J. (2009) Compositions, Methods and Related Uses for Cleaving Modified DNA. US8969061B2.

12. Roberts, R.J., Zheng, Y. (2010) Selection and enrichment of proteins using in vitro compartmentalization. EP2008/2,118,280.

13. Roberts, R.J., Zheng, Y. (2012) Selection and enrichment of proteins using in vitro compartmentalization. US8,153,358.

14. Morgan, R.D., Roberts, R.J. (2012) Restriction endonucleases, DNA encoding these endonucleases and methods for identifying new endonucleases with the same or varied specificity. US8227231B2

15. Zheng, Y., Saleh, L., Pais, J., Dai, N., Roberts, R.J., Correa, I.R.JR., Mabuchi, M., Vaisvila, R. (2013) Composition and methods of oxygenation of nucleic acids containing 5-methylpyrimidine. US20150132750A9.