那曼丽：博士，资格研究员，研究领域:  微生物感染与炎症

电子邮箱: naml809@ujs.edu.cn            

教育背景                
  2000.9-2004.7   东北师范大学，生命科学学院， 国家生物学基础科学研究和教学人才培养基地班，生物技术专业，学士
  2004.9-2007.7   浙江理工大学，新元生物医学与生物技术研究所，生物化学与分子生物学，硕士
  2008.2-2013.2  瑞典隆德大学，生物医学中心临床科学系，生物医学与分子医学，博士
    

工作经历              
  2007.2-2008.2 瑞典隆德大学，生物医学中心临床科学系，国际交换生

2014.6-2015.12 瑞典哥德堡大学，撒格林氏卡医学院风湿与炎症研究系，博士后

2016.1-2017.12 瑞典哥德堡大学，撒格林氏卡医学院风湿与炎症研究系，实验室主管
  2018.9-2020.12 瑞典哥德堡大学，撒格林氏卡医学院风湿与炎症研究系，助理教授

2021.8-现在     江苏大学，国际基因组学研究中心，资格研究员

发表文章

以第一作者发表的文章

(1)      Manli   Na,   Zhicheng Hu, Majd Mohammad, Mariana do Nascimento Stroparo,   Abukar Ali, Ying Fei, Anders Jarneborn, Peter Verhamme, Olaf Schneewind,   Dominique M. Missiakas, Tao Jin. The von   Willebrand factor-binding protein determines the joint-invading   capacity of staphylococcus aureus - a core   mechanism of septic arthritis. mBIO. 2020 Nov 17;11(6):e02472-20. doi: 10.1128/mBio.02472-20. PMID: 33203754.

(2)        Manli Na, Majd Mohammad, Ying Fei, Wanzhong Wang, André Holdfeldt, Huamei Forsman, Abukar Ali, Rille Pullerits, Tao Jin. Lack of Receptor for Advanced Glycation   end Products leads to less severe staphylococcal skin infection but more skin   abscesses and prolonged wound healing. Journal of Infectious Diseases. 2018 Jul 24;218(5):791-800. PMID: 29329449.

(3)        Manli Na, Wanzhong Wang, Ying Fei, Elisabet Josefsson, Abukar   Ali, Tao Jin. Both anti-TNF and CTLA4-Ig treatments attenuate the disease   severity of staphylococcal dermatitis in mice. PLoS One. 2017 Mar 6; 12(3): e0173492. PMID: 28264025.

(4)        Manli Na, Anders Jarneborn, Abukar Ali, Amanda   Welin, Malin Magnusson, Anna Stokowska, Marcela Pekna, Tao Jin. Deficiency of the complement component 3   but not factor B aggravates Staphylococcal aureus septic arthritis in   mice. Infection and Immunity. 2016 Mar 24;84(4):930-9. PMID: 26787717.

(5)        Manli Na, Dongfeng Chen, Bo Holmqvist, Liang Ran,   Jie Jin, Johan Rebetz, Xiaolong Fan. Adenovirus assembly is impaired by BMI1-related   histone deacetylation activity. Virology, 2014,   456-457: 227-237. PMID: 24889242.

(6)        Manli Na, and Xiaolong Fan. Design of Ad5F35 vectors for coordinated dual gene   expression in candidate human hematopoietic stem cells. Experimental Hematology, 2010, 38(6): 446–452. PMID: 20303383.

国际合作文章

(7)        Marco Maugeri, Muhammad   Nawaz, Alexandros Papadimitriou, Annelie Angerfors, Alessandro Camponeschi, Manli   Na, Mikko Hölttä, Pia Skantze, Svante Johansson, Martina Sundqvist,   Johnny Lindquist, Tomas Kjellman, Inga-Lill Mårtensson, Tao Jin, Per   Sunnerhagen, Sofia Östman, Lennart Lindfors, Hadi Valadi. Linkage between endosomal escape of   LNP-mRNA and loading into EVs for transport to other cells. Nature Communications. 2019 Sep 24; 10(1):4333. PMID:   31551417.

(8)        Emma Boldock, Bas G J   Surewaard, Daria Shamarina, Manli Na, Ying Fei, Abukar Ali,   Alexander Williams, Eric J G Pollitt, Piotr Szkuta, Paul Morris, Tomasz K   Prajsnar, Kathy D McCoy, Tao Jin, David H Dockrell, Jos A G van Strijp, Paul   Kubes, Stephen A Renshaw, Simon J Foster. Human skin commensals augment Staphylococcus aureus   pathogenesis. Nature Microbiology. 2018 Aug;3(8):881-890. PMID: 30013237.

第二作者的文章

(9)        Majd Mohammad, Manli   Na, Zhicheng Hu, Minh-thu Nguyen, Pradeep Kumar Kopparapu, Anders   Jarneborn, Anna Karlsson, Abukar Ali, Rille Pullerits, Friedrich Götz, Tao   Jin. Staphylococcus aureus   lipoproteins promote abscess formation in mice, shielding bacteria from   immune killing. Communications   Biology. 2021 Mar   30;4(1):432. doi: 10.1038/s42003-021-01947-z. PMID: 33785850.

(10)    Majd Mohammad, Manli   Na, Amanda Welin, Mattias Svensson, Abukar Ali, Malin Magnusson, Tao   Jin, Rille Pullerits. RAGE   deficiency impairs the bacterial clearance in murine staphylococcal sepsis,   but has no significant impact on staphylococcal septic arthritis. PLoS One. 2016 Dec 1; 11(12): e0167287. PMID: 27907047.

(11)    Jakub Kwiecinski, Manli   Na, Anders Jarneborn, Gunnar Jacobsson, Marijke Peetermans, Peter   Verhamme, Tao Jin. Tissue   plasminogen activator coating on surface of implants reduces Staphylococcus   aureus biofilm formation. Applied   And Environmental Microbiology.   2015 Oct 30; 82(1):394-401. PMID: 26519394.

(12)    Abukar Ali, Manli   Na, Mattias N.D. Svensson, Malin Magnusson, Amanda Welin,   Jan-Christoph Schwarze, Majd Mohammad, Elisabet Josefsson, Rille Pullerits,   Tao Jin. IL-1   receptor antagonist treatment aggravates staphylococcal septic arthritis and   sepsis in mice. PLoS One. 2015 Jul 2; 10(7): e0131645.   PMID:26135738.

(13)    Johan Rebetz, Manli Na, Changqing Su, Bo Holmqvist, Anna Edqvist, Cecilia   Nyberg, Bengt Widegren, Leif G. Salford, Hans Olov Sjögren, Niklas Arnberg,   Qijun Qian, and Xiaolong Fan. Fiber mediated receptor masking in   non-infected bystander cells restricts adenovirus cell killing effect but   promotes adenovirus host co-existence. PLoS One,   2009, 4 (12): e8484. PMID: 20041185.

(14)    Changqing Su, Manli   Na, Jie Chen, Xinghua Wang, Yongjing Liu, Weiguo Wang, Qi   Zhang, Linfang Li, Ju Long, Xinyuan Liu, Mengchao Wu, Xiaolong Fan, and Qijun   Qian. Gene-viral cancer   therapy using dual-regulated oncolytic adenovirus with antiangiogenesis gene   for increased efficacy. Molecular   Cancer Research, 2008, 6   (4): 568-575. PMID: 18344493.

指导博士生发表的文章

(15)    Anders Jarneborn, Majd   Mohammad, Cecilia Engdahl, Zhicheng Hu, Manli Na, Abukar Ali,   Tao Jin. Tofacitinib   treatment aggravates Staphylococcus aureus septic arthritis, but attenuates   sepsis and enterotoxin induced shock in mice. Scientific Reports. 2020 Jul 2;10(1):10891. doi:   10.1038/s41598-020-67928-0. PMID: 32616791.

(16)    Majd Mohammad, Minh-Thu   Nguyen, Cecilia Engdahl, Manli Na, Anders Jarneborn, Zhicheng   Hu, Anna Karlsson, Rille Pullerits, Abukar Ali, Friedrich Götz, Tao Jin. The YIN and YANG of lipoproteins in   developing and preventing infectious arthritis by Staphylococcus aureus. PLoS   Pathogens. 2019 Jun 21; 15(6):e1007877. PMID: 31226163.

(17)    Majd Mohammad, Zhicheng   Hu, Abukar Ali, Pradeep Kumar Kopparapu, Manli Na, Anders   Jarneborn, Mariana do Nascimento Stroparo, Minh-thu Nguyen, Anna Karlsson,   Friedrich Götz, Rille Pullerits, Tao Jin. The role of Staphylococcus aureus lipoproteins in   hematogenous septic arthritis. Scientific   Reports. 2020 May 13;10(1):7936.   doi: 10.1038/s41598-020-64879-4. PMID: 32404866.

(18)    Farah Fatima, Ying Fei,   Abukar Ali, Majd Mohammad, Malin C. Erlandsson, Maria I. Bokarewa, Muhammad   Nawaz, Hadi Valadi, Manli Na, Tao Jin. Radiological features of experimental staphylococcal   septic arthritis by micro computed tomography scan. PLoS One. 2017 Feb 2; 12(2): e0171222. PMID: 28152087.

其他合作文章

(19)    Jakub Kwiecinski, Marijke Peetermans, Laurens Liesenborghs, Manli Na, Halla Björnsdottir, Xuefeng Zhu, Gunnar Jacobsson, Bengt R.   Johansson, Joan A. Geoghegan, Timothy J. Foster, Elisabet Josefsson, Johan   Bylund, Peter Verhamme, Tao Jin. Staphylokinase control of Staphylococcus aureus biofilm formation and   detachment through host plasminogen activation. Journal of Infectious Diseases. 2016 Jan 1; 213(1):139-48. PMID: 26136471.

(20)    Jonas Elmwall, Jakub   Kwiecinski, Manli Na, Abukar Ahmed Ali, Veronica Osla, Lindsey   Shaw, Wanzhong Wang, Karin Sävman, Elisabet Josefsson, Johan Bylund, Tao Jin,   Amanda Welin, Anna Karlsson. Galectin-3   is a target for proteases involved in the virulence of Staphylococcus aureus.   Infection and Immunity. 2017 Jun 20;85(7). pii: e00177-17. PMID: 28438975.

(21)    Abukar Ali, Amanda   Welin, Jan-Christoph Schwarze, Mattias N.D. Svensson, Manli Na,   Anders Jarneborn, Malin Magnusson, Majd Mohammad, Jakub Kwiecinski, Elisabet   Josefsson, Johan Bylund, Rille Pullerits, Tao Jin. CTLA4-Ig but not anti-TNF therapy promotes staphylococcal   septic arthritis in mice. Journal   of Infectious Diseases. 2015   Oct 15;212(8):1308-16. PMID: 25838268.

(22)    Dongfeng Chen, Duo Zuo,   Cheng Luan, Min Liu, Manli Na, Liang Ran, Yingyu Sun, Annette   Persson, Elisabet Englund, Leif G. Salford, Erik Renström, Xiaolong Fan,   Enming Zhang. Glioma cell   proliferation controlled by ERK activity-dependent surface expression of   PDGFRA. PLoS One, 2014, 9(1): e87281. PMID: 24489888.

(23)    Lin Chen, Dongfeng   Chen, Mouchun Gong, Manli Na, Linfang Li, Hongping Wu, Lihua   Jiang, Yanzhen Qian, Guoen Fang, and Xuchao Xue. Concomitant use of Ad5/35   chimeric oncolytic adenovirus with TRAIL gene and taxol produces synergistic   cytotoxicity in gastric cancer cells. Cancer Letters, 2009, 284(2): 141-148. PMID: 19447545.

承担主要科研项目

主持项目

(1)        Targeting   fibrinolysis for prevention and treatment of Biofilm-associated   Staphylococcus aureus infections. Adlerbertska   Research Foundation. 50 000 SEK. 2019-09 to 2020-12.

(2)        Molecular etiology of   staphylococcal joint infections. The Royal Society of Arts and Sciences in   Gothenburg (KVVS). 40 000 SEK. 2019-06 to 2020-12.

(3)        Molecular etiology of   staphylococcal joint infections. Adlerbertska Research Foundation.   24 000 SEK. 2017-09 to 2018-12.

(4)        Molecular etiology of   staphylococcal joint infections. Adlerbertska Research Foundation.   29 000 SEK. 2016-09 to 2017-12.

(5)        Targeting   fibrinolysis for prevention and treatment of Biofilm-associated   Staphylococcus aureus infections. Adlerbertska   Research Foundation. 25 000 SEK. 2015-09 to 2016-12.

(6)        Targeting   fibrinolysis for prevention and treatment of Biofilm-associated   Staphylococcus aureus infections. The Royal Society of Arts and Sciences in   Gothenburg (KVVS). 45 000 SEK. 2015-06 to 2016-12.

(7)        Interleukin 33 and   novel therapeutic approaches in Staphylococcus aureus septic arthritis. Wilhelm and Martina Lundgren Foundation.   10 000 SEK. 2015-05 to 2016-12.

主要负责的项目

(8)        Molecular mechanism,   early diagnostics, and novel treatments for septic arthritis. Swedish   Research Council (VR). 800 000 SEK. Third applicant.   2020-01 to 2022-12.

(9)        Molecular Etiology   and novel therapies for Staphylococcal Joint Infections. ALF agreement. 1   000 000 SEK. Second applicant. 2019-01 to 2020-12.

(10)    Molecular etiology of   staphylococcal joint infections. Swedish Research Council (VR). 1   850 000 SEK. Second applicant. 2017-01 to 2021-01.