Personal information: Manli Na, Professor
Research field: Infection and inflammation
E-mail: naml809@ujs.edu.cn
Education background
2008.02-2013.02 Biomedicine Center, Institution of Clinical Sciences, Lund University, Sweden. Ph.D. in Biomedicine and Molecular Medicine
2004.09-2007.07 Xinyuan Institute of Medicine and Biotechnology, Zhejiang Sci-Tech University. Master in Biochemistry and Molecular Biology
2000.09-2004.07 College of Life Science, Northeast Normal University. Bachelor in Biotechnology
Academic background
2021.08-Now International Genome Center, College of Life Science, Jiangsu University. Professor
2018.09-2020.12 Department of Rheumatology and Inflammation Research, Gothenburg University, Sweden. Assistant professor
2016.01-2017.12 Department of Rheumatology and Inflammation Research, Gothenburg University, Sweden. Laboratory Supervisor
2014.06-2015.12 Department of Rheumatology and Inflammation Research, Gothenburg University, Sweden. Post-doc fellowship
2007.02-2008.02 Biomedicine Center, Institute of Clinical Sciences, Lund University, Sweden. International Exchange Student
Key scientific research projects
1.National Natural Science Foundation of China. Pathogenic mechanism of vWbp-mediated vascular adhesion in Staphylococcus aureus joint invasion，2023.01-2025.12，300 000 RMB.
2.Senior Talent Launch Fund of Jiangsu University. Development and treatment of novel biological agents for Staphylococcus aureus infection diseases. 2022.01-2025.12，400 000 RMB.
3.Swedish Research Council (VR). Molecular mechanism, early diagnostics, and novel treatments for septic arthritis. 2020.01-2022.12; 800 000 SEK.
4.Adlerbertska Research Foundation. Targeting fibrinolysis for prevention and treatment of Biofilm-associated Staphylococcus aureus infections. 2019.09-2020.12; 50 000 SEK.
5.The Royal Society of Arts and Sciences in Gothenburg (KVVS). Molecular etiology of staphylococcal joint infections. 2019.06-2020.12; 40 000 SEK.
6.ALF agreement. Molecular Etiology and novel therapies for Staphylococcal Joint Infections. 2019.01-2020.12; 1 000 000 SEK.
7.Swedish Research Council (VR). Molecular etiology of staphylococcal joint infections. 2017.01-2021.01; 1 850 000 SEK.
8.The Royal Society of Arts and Sciences in Gothenburg (KVVS). Targeting fibrinolysis for prevention and treatment of Biofilm-associated Staphylococcus aureus infections. 2015.06-2016.12; 45 000 SEK.
Main achievements
1.Manli Na, Zhicheng Hu, Majd Mohammad, Mariana do Nascimento Stroparo, Abukar Ali, Ying Fei, Anders Jarneborn, Peter Verhamme, Olaf Schneewind, Dominique M. Missiakas, Tao Jin. The von Willebrand factor-binding protein determines the joint-invading capacity of staphylococcus aureus - a core mechanism of septic arthritis. mBIO. 2020 Nov 17;11(6):e02472-20. doi: 10.1128/mBio.02472-20. PMID: 33203754.
2.Manli Na, Majd Mohammad, Ying Fei, Wanzhong Wang, André Holdfeldt, Huamei Forsman, Abukar Ali, Rille Pullerits, Tao Jin. Lack of Receptor for Advanced Glycation end Products leads to less severe staphylococcal skin infection but more skin abscesses and prolonged wound healing. Journal of Infectious Diseases. 2018 Jul 24;218(5):791-800. PMID: 29329449.
3.Manli Na, Wanzhong Wang, Ying Fei, Elisabet Josefsson, Abukar Ali, Tao Jin. Both anti-TNF and CTLA4-Ig treatments attenuate the disease severity of staphylococcal dermatitis in mice. PLoS One. 2017 Mar 6; 12(3): e0173492. PMID: 28264025.
4.Manli Na, Anders Jarneborn, Abukar Ali, Amanda Welin, Malin Magnusson, Anna Stokowska, Marcela Pekna, Tao Jin. Deficiency of the complement component 3 but not factor B aggravates Staphylococcal aureus septic arthritis in mice. Infection and Immunity. 2016 Mar 24;84(4):930-9. PMID: 26787717.
5.Manli Na, Dongfeng Chen, Bo Holmqvist, Liang Ran, Jie Jin, Johan Rebetz, Xiaolong Fan. Adenovirus assembly is impaired by BMI1-related histone deacetylation activity. Virology, 2014, 456-457: 227-237. PMID: 24889242.
6.Manli Na, and Xiaolong Fan. Design of Ad5F35 vectors for coordinated dual gene expression in candidate human hematopoietic stem cells. Experimental Hematology, 2010, 38(6): 446–452. PMID: 20303383.
7.Marco Maugeri, Muhammad Nawaz, Alexandros Papadimitriou, Annelie Angerfors, Alessandro Camponeschi, Manli Na, Mikko Hölttä, Pia Skantze, Svante Johansson, Martina Sundqvist, Johnny Lindquist, Tomas Kjellman, Inga-Lill Mårtensson, Tao Jin, Per Sunnerhagen, Sofia Östman, Lennart Lindfors, Hadi Valadi. Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells. Nature Communications. 2019 Sep 24; 10(1):4333. PMID: 31551417.
8.Emma Boldock, Bas G J Surewaard, Daria Shamarina, Manli Na, Ying Fei, Abukar Ali, Alexander Williams, Eric J G Pollitt, Piotr Szkuta, Paul Morris, Tomasz K Prajsnar, Kathy D McCoy, Tao Jin, David H Dockrell, Jos A G van Strijp, Paul Kubes, Stephen A Renshaw, Simon J Foster. Human skin commensals augment Staphylococcus aureus pathogenesis. Nature Microbiology. 2018 Aug;3(8):881-890. PMID: 30013237.
9.Majd Mohammad, Manli Na, Zhicheng Hu, Minh-thu Nguyen, Pradeep Kumar Kopparapu, Anders Jarneborn, Anna Karlsson, Abukar Ali, Rille Pullerits, Friedrich Götz, Tao Jin. Staphylococcus aureus lipoproteins promote abscess formation in mice, shielding bacteria from immune killing. Communications Biology. 2021 Mar 30;4(1):432. doi: 10.1038/s42003-021-01947-z. PMID: 33785850.
10.Majd Mohammad, Manli Na, Amanda Welin, Mattias Svensson, Abukar Ali, Malin Magnusson, Tao Jin, Rille Pullerits. RAGE deficiency impairs the bacterial clearance in murine staphylococcal sepsis, but has no significant impact on staphylococcal septic arthritis. PLoS One. 2016 Dec 1; 11(12): e0167287. PMID: 27907047.
11.Jakub Kwiecinski, Manli Na, Anders Jarneborn, Gunnar Jacobsson, Marijke Peetermans, Peter Verhamme, Tao Jin. Tissue plasminogen activator coating on surface of implants reduces Staphylococcus aureus biofilm formation. Applied And Environmental Microbiology. 2015 Oct 30; 82(1):394-401. PMID: 26519394.
12.Abukar Ali, Manli Na, Mattias N.D. Svensson, Malin Magnusson, Amanda Welin, Jan-Christoph Schwarze, Majd Mohammad, Elisabet Josefsson, Rille Pullerits, Tao Jin. IL-1 receptor antagonist treatment aggravates staphylococcal septic arthritis and sepsis in mice. PLoS One. 2015 Jul 2; 10(7): e0131645. PMID:26135738.
13.Johan Rebetz, Manli Na, Changqing Su, Bo Holmqvist, Anna Edqvist, Cecilia Nyberg, Bengt Widegren, Leif G. Salford, Hans Olov Sjögren, Niklas Arnberg, Qijun Qian, and Xiaolong Fan. Fiber mediated receptor masking in non-infected bystander cells restricts adenovirus cell killing effect but promotes adenovirus host co-existence. PLoS One, 2009, 4 (12): e8484. PMID: 20041185.
14.Changqing Su, Manli Na, Jie Chen, Xinghua Wang, Yongjing Liu, Weiguo Wang, Qi Zhang, Linfang Li, Ju Long, Xinyuan Liu, Mengchao Wu, Xiaolong Fan, and Qijun Qian. Gene-viral cancer therapy using dual-regulated oncolytic adenovirus with antiangiogenesis gene for increased efficacy. Molecular Cancer Research, 2008, 6 (4): 568-575. PMID: 18344493.
